Anus and perianal area
Highly differentiated squamous lesion
Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 16 April 2013, last major update April 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Highly differentiated squamous lesion that appears to be invasive
● Composed of large, mature squamous cells except at base and edges, which have more undifferentiated cells with mitotic activity
● Epithelium is acanthotic and hyperkeratotic; lamina propria has lymphoplasmacytic infiltrate
● May be invasive, but local excision appears to be curative
End of Anus and perianal area > Carcinoma > Highly differentiated squamous lesion
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