Anus and perianal area
Other malignancies
Gastrointestinal stromal tumor

Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 October 2017, last major update April 2005

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Gastrointestinal stromal tumor anus

Cite this page: Pernick, N. Gastrointestinal stromal tumor. PathologyOutlines.com website. http://pathologyoutlines.com/topic/anusGIST.html. Accessed November 20th, 2017.
Definition / general
  • Anorectal GISTS usually occur in men (70% ), age 40+
  • Small asymptomatic intramural nodules to large masses that bulge into pelvis causing pain, rectal bleeding or obstruction
  • May have late recurrence and distant metastases to liver, bone, lungs
Clinical features
Prognostic factors
Microscopic (histologic) description
  • Usually highly cellular spindle cell tumors
  • Occasionally epithelioid morphology
Positive stains
Negative stains