Adrenal gland and paraganglia
Adrenocortical carcinoma
Features to report

Author: Debra Zynger, M.D. (see Authors page)

Revised: 8 August 2017, last major update August 2017

Copyright: (c) 2002-2017,, Inc.

Cite this page: Adrenocortical carcinoma - Features to report . website. Accessed August 23rd, 2017.
Weiss Criteria
    Weiss criteria can be evaluated to determine malignant potential:

  • High nuclear grade
  • Mitotic rate >5 mitoses per 50 high-powered (40x) fields
  • Atypical mitotic figures
  • < 25% clear cells
  • Diffuse architecture
  • Necrosis
  • Venous invasion
  • Sinusoidal invasion
  • Capsular invasion
Required features to report
The following items are necessary to establish the 8th edition AJCC pTNM stage:

  • Size (5 cm or less or > 5 cm)
  • Tumor extent (into extra-adrenal tissue or adjacent organs, renal vein or vena cava)
  • Regional lymph node status
  • Distant metastasis (if applicable)