Adrenal gland and paraganglia
Other benign cortical lesions
Myelolipoma

Author: Lan L. Gellert, M.D., Ph.D. (see Authors page)

Revised: 27 January 2017, last major update January 2017

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: adrenal myelolipoma
Cite this page: Myelolipoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/adrenalmyelolipoma.html. Accessed October 21st, 2017.
Definition / general
  • Benign and usually unilateral tumor composed of hematopoietic precursor cells and mature fat
  • Usually an incidental autopsy finding or CT / MRI finding
  • Not associated with hematologic disorders; nonfunctioning
Essential features
  • Benign and usually unilateral tumor composed of hematopoietic precursor cells and mature fat
  • Usually an incidental finding
  • Not associated with hematologic disorders; nonfunctioning
Epidemiology
  • No gender predilection
  • Typically in the fifth to seventh decade of life
Etiology
  • May due to metaplastic change in the reticuloendothelial cells in response to stimuli including necrosis, infection or stress (Int J Urol 2005;12:239)
Case reports
Treatment
  • Follow up or excision if symptomatic
Clinical images

Images hosted on other servers:

Abdominal US scan

CT abdomen findings

MRI scan findings

Giant bilateral myelolipomas of abdomen

Axial section of
computed tomogram
showing mass in right
supra renal gland

Gross description
  • Nonencapsulated, bright yellow adipose-like tissue with hemorrhagic foci (contains marrow tissue)
  • May be up to 5 kg
Gross images

Images hosted on PathOut server:

Contributed by Dr. Lan Gellert



Images hosted on other servers:

Bright yellow, and focally red, fatty tumor with extensive hemorrhage

Gross specimen of left adrenal myelolipoma


Gross appearance of adrenal myelolipoma

Grey / brown / yellowish areas with areas of hemorrhage

Intraoperative picture showing large suprarenal mass

Well circumscribed
tumor with multiple
areas of hemorrhage

Microscopic (histologic) description
  • Islands of hematopoietic cells and mature fat
  • Usually show normal trilineage hematopoiesis, but often with markedly increased megakaryocytes
  • Larger tumors may have hemorrhage, necrosis, calcification and cysts
  • Rarely may have areas of fibromyxoid degeneration resembling low grade fibromyxoid sarcoma
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Dr. Lan Gellert:

Various images



Images hosted on other servers:

Various images - mature adipose and hematopoietic cells


H&E stain of left adrenal myelolipoma

Classic tumor

With ganglioneuroma

Matured adipose tissue, bone marrow elements, adjoining adrenal tissue and capsule