Adrenal gland
Other benign cortical lesions
Massive macronodular adrenocortical disease

Author: Lan L. Gellert, M.D., Ph.D. (see Authors page)

Revised: 14 January 2017, last major update January 2017

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: Massive Macronodular Adrenocortical Disease
Cite this page: Massive macronodular adrenocortical disease. PathologyOutlines.com website. http://pathologyoutlines.com/topic/adrenalmassivemacronodular.html. Accessed June 24th, 2017.
Definition / general
Essential features
  • ACTH independent multinodular adrenocortical proliferation
  • Usually bilateral
  • Occasionally associated with hereditary leiomyomatosis and renal cell cancer (HLRCC) or McCune-Albright syndrome
Clinical features
  • Usually present with either typical or atypical Cushing syndrome
Case reports
Treatment
  • Adrenalectomy
Clinical images

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Macronodular adrenocortical
hyperplasia of the zona reticularis

Gross description
  • Glands up to 180 g, nodules up to 4 cm and nonnodular cortex may be atrophic
Gross images

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AIMAH patient 1

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AIMAH patient 2

Microscopic (histologic) description
  • Predominantly diffuse and vaguely nodular proliferation of clear cortical cells
Microscopic (histologic) images

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A quantitative RT-PCR array

Positive stains
Differential diagnosis