Cite this page: Hereditary unresponsiveness to ACTH. PathologyOutlines.com website. http://pathologyoutlines.com/topic/adrenalhereditaryunresponsiveness.html. Accessed September 22nd, 2017.
Definition / general
- Rare; due to abnormalities of ACTH receptor in adrenocortical cells
- Seizures, hypoglycemia, muscle weakness and hyperpigmentation similar to Addisons disease
- Low plasma cortisol levels, increased serum ACTH
Microscopic (histologic) description
- Normal zona glomerulosa, atrophic zona fasciculata and reticularis