Adrenal gland and paraganglia
Other benign cortical lesions
Solitary fibrous tumor

Author: Lan Gellert, M.D., Ph.D. (see Authors page)
Editorial Board Review: Debra L. Zynger, M.D.

Revised: 12 April 2017, last major update March 2017

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: solitary fibrous tumor adrenal gland

Cite this page: Solitary fibrous tumor. PathologyOutlines.com website. http://pathologyoutlines.com/topic/adrenalSFT.html. Accessed October 18th, 2017.
Essential features
  • Extremely rare
  • Bland spindle cell proliferation with patternless architecture and staghorn vessels
  • Has characteristic NAB2-STAT6 gene fusion
  • Biologic behavior variable, mostly benign with rare recurrence or metastasis
Prognostic factors
  • Biologic behavior variable and unpredictable
  • Nuclear atypia, hypercellularity, greater than 4 mitoses/10 HPFs and necrosis may be associated with, but is not predictive of, aggressive clinical behavior (Am J Surg Pathol 1998;22:1501)
Case reports
Treatment
  • Complete surgical resection
Gross description
  • White tan, solid, well circumscribed and partially encapsulated neoplasm
Microscopic (histologic) description
  • Bland spindle cell proliferation with patternless architecture and staghorn vessels
  • Nuclear atypia, hypercellularity, greater than 4 mitoses/10 HPFs and necrosis may associated with, but is not entirely predictive of, aggressive clinical behavior (Am J Surg Pathol 1998;22:1501)
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Lan Gellert, M.D., Ph.D.

Various images


Staghorn vessels with occasional perivascular fibrosis


Patternless architecture with collagen deposition

CD34

BCL2

Positive stains
Negative stains
Differential diagnosis
  • Ganglioneuroma: ganglion cells are present; S100+
  • Gastrointestinal stromal tumor: spindle cells in whorls or short intersecting fascicles, with occasional nuclear palisading and perinuclear vacuoles; CD117+, DOG1+
  • Schwannoma and neurofibroma: elongate, wavy neoplastic cells with tapered ends; S100+
  • Smooth muscle tumors: tumor cells arranged in intersecting fascicles; nuclei round at both ends, with occasional cytoplasmic vacuoles; desmin+, SMA+
  • Synovial sarcoma: spindle cells arranged in fascicles, sometimes with biphasic morphology; t(X;18)