Soft Tissue

Authors / Editors: Komal Arora, M.D., Jerad Gardner, M.D., Raul Gonzalez, M.D., Ashley Gullett, M.D., Christine E. Jabcuga, M.D., David Lucas, M.D., Annie S. Morrison, M.D., Nat Pernick, M.D., Deepti Reddi, M.D., Vijay Shankar, M.D., Lauren N. Stuart M.D., M.B.A., Daniel Wimmer, D.O. (see Authors page)

Revised: 1 September 2015, updated June 2013

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

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Table of contents

General: primary referencessoft tissue-normalsarcomas-generalapproach to diagnosisarchitectural patternscell typesgradingmolecularstagingsyndromes

Infections, inflammation and hematoma: generalgranulomatoushematomanecrotizing fasciitisPVP granulomatumoral calcinosis

Tumors
Adipose tissue: embryology & physiologywhite fatbrown fat
lipoma and variants: lipomaangiolipomachondroidfibrolipomaintramuscularlipoma arborescenslipoma of tendon sheathlipomatosislipomatosis of nervelumbosacralmyolipomamyxoidnevus lipomatosuspelvicpleomorphic / spindle cell
other benign lesions: hemosiderotic fibrohistiocytichibernomalipoblastomasubconjunctival herniated orbital fat
liposarcoma: generalatypical lipomatous tumor / well differentiated ( variants: inflammatorylipoleiomyosarcomadedifferentiated )   myxoid-generalmyxoid-well differentiatedmyxoid-round cellpleomorphicmixed typesclerosing poorly differentiated

Extraskeletal bone tumors: aneurysmal bone cystchondromachondrosarcomachordomaEwing/PNETosteosarcomaparachordoma

Fibroblastic / myofibroblastic: generalfibroblastic/myofibroblastic - normalangiofibromaangiomyofibroblastomacalcifying aponeurotic fibromacalcifying fibrous tumorcellular angiofibromadermatofibrosarcoma protuberansdesmoplastic fibroblastomaelastofibromaeosinophilic fasciitisfibroma of tendon sheathfibromatosis-generalfibromatosis-superficialfibromatosis-deepfibromatosis collifibrosarcoma-adultfibrosarcoma-infantilefibrous hamartoma of infancyfocal myositisGardner fibromagiant cell angiofibromagiant cell fibroblastomahemangiopericytomainclusion body fibromatosisinflammatory myofibroblastic tumorintranodal palisaded myofibroblastomaischemic fasciitisjuvenile hyaline fibromatosislipofibromatosislow grade fibromyxoid sarcomalow grade myofibroblastic sarcomamammary type myofibroblastomamyofibroma / myofibromatosismyositis ossificansmyxofibrosarcomamyxoinflammatory fibroblastic sarcomanodular fasciitis and related lesionsnuchal fibrocartilaginous pseudotumornuchal type fibromaossifying fibromyxoid tumorpleomorphic fibromaproliferative fasciitisproliferative myositisproliferative peribursitissclerosing epithelioid fibrosarcomasolitary fibrous tumorsuperficial acral fibromyxoma

Fibrohistiocytic: benign fibrous histiocytoma and variants: superficialdeepaneurysmalangiomatoidatypicalcellularepithelioidjuvenile xanthogranuloma
other benign lesions: generalatypical fibroxanthomagiant cell tumor of soft tissuegiant cell tumor of tendon sheath-diffusegiant cell tumor of tendon sheath-localizedMFH-giant cellMFH-inflammatoryMFH-pleomorphicPHATplexiform fibrohistiocytic tumor

Mesenchymal: hamartomamesenchymomaphosphaturic mesenchymal tumor

Peripheral nerve:
neurofibroma: generalpacinianpigmentedplexiformneurofibromatosis type 1type 2
other benign: normalmyxopapillary ependymomanerve sheath myxomaneuromaneurothekeomaperineuriomapigmented neuroectodermal tumor of infancyschwannoma
malignant: lymphomaMPNST

Perivascular epithelioid cell: PEComa-generalabdominopelvic sarcomafalciform ligament / ligamentum teres

Skeletal Muscle: skeletal muscle-normalneuromuscular hamartomamyxoma
rhabdomyoma: adultfetalgenital
rhabdomyosarcoma: generalalveolaranaplasticembryonalpleomorphicsclerosing

Smooth Muscle: generalangioleiomyomaEBV-related
leiomyoma: classicbizarrecutaneousepithelioidgenitaldeep soft tissue
leiomyosarcoma: generalcutaneousepithelioidmyxoidpleomorphicrhabdoid features

Vascular:
normal/benign: normalbacillary angiomatosisglomushemangioma-general-microvenular-symplasticintravascular papillary endothelial hyperplasiamyopericytomavascular ectasias
low/intermediate grade: giant cell angioblastomahemangioendotheliomaKaposi sarcoma
high grade: angiosarcomaintimal sarcoma
Lymphangioma: -general-cystic-post-radiationlymphangiomatosislymphangioendotheliomalymphangiomyomalymphangiosarcoma

Other: alveolar soft part sarcomaclear cell sarcomadesmoplastic small round cell tumorepithelioid sarcomagranular cell tumormetastasesmyoepithelial carcinomamyospherulosismyxomarhabdoid tumorsinus histiocytosis with massive lymphadenopathysynovial sarcomateratoma

Superpages: part 1 (normal to extraskeletal bone tumors)part 2 (fibroblastic / myofibroblastic)part 3 (fibrohistiocytic to perivascular epithelioid cell)part 4 (skeletal muscle to other)


Index (Alphabetical Table of Contents)
A-E: adipose: embryology & physiologyalveolar soft part sarcomaaneurysmal BFHangiofibromaangioleiomyomaangiolipomaangiomatoid BFHangiomyofibroblastomaangiosarcomaapproach to diagnosisarchitectural patternsatypical BFHatypical fibroxanthomaatypical lipomatous tumor / well differentiatedbacillary angiomatosisbenign fibrous histiocytoma (superficial)brown fatcalcifying aponeurotic fibromacalcifying fibrous tumorcell typescellular angiofibromacellular BFHchondroid lipomaclear cell sarcomadedifferentiated liposarcomadeep benign fibrous histiocytomadermatofibrosarcoma protuberansdesmoplastic fibroblastomadesmoplastic small round cell tumorEBV-related smooth muscleelastofibromaeosinophilic fasciitisepithelioid BFHepithelioid sarcomaextraskeletal aneurysmal bone cystextraskeletal chondromaextraskeletal chondrosarcomaextraskeletal chordomaextraskeletal Ewing/PNETextraskeletal osteosarcoma

F-J: fibroblastic/myofibroblastic - generalfibroblastic/myofibroblastic - normalfibrohistiocytic-generalfibrolipomafibroma of tendon sheathfibromatosis collifibromatosis-deepfibromatosis-generalfibromatosis-superficialfibrosarcoma-adultfibrosarcoma-infantilefibrous hamartoma of infancyfocal myositisGardner fibromagiant cell angioblastomagiant cell angiofibromagiant cell fibroblastomagiant cell tumor of soft tissuegiant cell tumor of tendon sheath-diffusegiant cell tumor of tendon sheath-localizedglomusgradinggranular cell tumorgranulomatoushemangioendotheliomahemangioma-general hemangioma-microvenular hemangioma-symplastichemangiopericytomahematomahemosiderotic fibrohistiocytic lipomatous lesionhibernomainclusion body fibromatosisinfections-generalinflammatory liposarcomainflammatory myofibroblastic tumorintimal sarcomaintramuscular lipomaintranodal palisaded myofibroblastomaintravascular papillary endothelial hyperplasiaischemic fasciitisjuvenile hyaline fibromatosisjuvenile xanthogranuloma

K-O: Kaposi sarcomaleiomyoma-bizarreleiomyoma-classicleiomyoma-cutaneousleiomyoma-deep soft tissueleiomyoma-epithelioidleiomyoma-genitalleiomyosarcoma-cutaneousleiomyosarcoma-epithelioidleiomyosarcoma-generalleiomyosarcoma-myxoidleiomyosarcoma-pleomorphicleiomyosarcoma-rhabdoid featureslipoblastomalipofibromatosislipoleiomyosarcomalipomalipoma arborescenslipoma of tendon sheathlipomatosislipomatosis of nerveliposarcoma-generallow grade fibromyxoid sarcomalow grade myofibroblastic sarcomalumbosacral lipomalymphangioma-generallymphangioma-cysticlymphangioma-post-radiationlymphangiomatosislymphangioendotheliomalymphangiomyomalymphangiosarcomalymphomamammary type myofibroblastomamesenchymal hamartomamesenchymomametastasesMFH-giant cellMFH-inflammatoryMFH-pleomorphic mixed type liposarcomamolecularMPNSTmyoepithelial carcinomamyofibroma / myofibromatosismyolipomamyopericytomamyositis ossificansmyospherulosismyxofibrosarcomamyxoid lipomamyxoid liposarcoma-generalmyxoid-round cell liposarcomamyxoid-well differentiated liposarcomamyxoinflammatory fibroblastic sarcomamyxomamyxopapillary ependymomanecrotizing fasciitisnerves-normalnerve sheath myxomaneurofibroma-generalneurofibroma-pacinianneurofibroma-pigmentedneurofibroma-plexiformneurofibromatosis type 1neurofibromatosis type 2neuromaneuromuscular hamartomaneurothekeomanevus lipomatosusnodular fasciitis and related lesionsnuchal fibrocartilaginous pseudotumornuchal type fibromaossifying fibromyxoid tumor

P-Z: parachordomaPEComaPEComa-abdominopelvic sarcomaPEComa-falciform ligament / ligamentum terespelvic lipomaperineuriomaphosphaturic mesenchymal tumorpigmented neuroectodermal tumor of infancypleomorphic fibromapleomorphic hyalinizing angiectatic tumorpleomorphic liposarcomapleomorphic / spindle cell lipomaplexiform fibrohistiocytic tumorprimary referencesproliferative fasciitisproliferative myositisproliferative peribursitisPVP granulomarhabdoid tumorrhabdomyoma-adultrhabdomyoma-fetalrhabdomyoma-genitalrhabdomyosarcoma-alveolarrhabdomyosarcoma-anaplasticrhabdomyosarcoma-embryonalrhabdomyosarcoma-generalrhabdomyosarcoma-pleomorphicrhabdomyosarcoma-sclerosingsarcomas-generalschwannomasclerosing epithelioid fibrosarcomasclerosing poorly differentiated liposarcomasinus histiocytosis with massive lymphadenopathyskeletal muscle-normalsmooth muscle generalsoft tissue-normalsolitary fibrous tumorsubconjunctival herniated orbital fatstagingsuperficial acral fibromyxomasyndromessynovial sarcomateratomatumoral calcinosisvascular ectasiasvasculature-normalwhite fat

Primary references
top

AJCC Cancer Staging Manual (7th ed)
Weiss: Soft Tissue Tumors (5th edition, 2007)
Fletcher:Pathology and Genetics of Tumours of Soft Tissue and Bone (AFIP 3rd Series, Vol 30), 2004
Fletcher:Pathology and Genetics of Tumours of Soft Tissue and Bone (WHO, Vol 5), 2002, PDF
Websites with images: PathoPicUSCAP (virtual slides)WebPathology.com



Recent Soft Tissue pathology books
 

Antonescu: 2013

Bilbao: 2014

Dodd: 2014

Doyle: 2015

Fisher: 2013

Fisher: 2010

Fletcher: 2013

Goldblum: 2013

Hornick: 2013

Horvai: 2012

Kempson: 2001

Khalbuss: 2010

Klijanienko: 2011

Layfield: 2012

Lindenberg: 2015

Miettinen: 2015

Montgomery: 2011

Picci: 2014


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