Skin - Nonmelanocytic tumors

Authors/Editors: Hillary Elwood, M.D., Christopher Hale, M.D., Aravindhan Sriharan, M.D., Ghassan Tranesh, M.D., Hong Qu, M.D. (see Authors page)

Editorial Board review: Sara C. Shalin, M.D., Ph.D

Revised: 31 August 2015, last major update - IN PROGRESS

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Benign (nonmelanotic) epidermal tumors or tumor-like lesions: acquired digital fibrokeratomaclear cell papulosiscutaneous hornfibroepithelial polyphair follicle nevuslarge cell acanthomamelanoacanthomapseudoepitheliomatous hyperplasiaseborrheic keratosisverruca vulgarisverrucous hyperplasia

Cysts: apocrine cystadenoma / hidrocytomabronchogenic cystcystadenomadermoid cystkeratinous cystpigmented follicular cyststeatocystomavellous hair cyst

Adnexal tumors: general
• Sweat gland derived (apocrine & eccrine glands): acrosyringeal adenomatosisadenoid cystic carcinoma (primary cutaneous)apocrine-generalapocrine mixed tumorapocrine tubular adenomachondroid syringomaclear cell acanthomaclear cell carcinoma with comedonecrosiscongenital eccrine angiomatous hamartomaeccrine cylindromaeccrine poromaeccrine spiradenomahidradenoma / eccrine acrospiromahidradenoma papilliferumintraepidermal epitheliomamicrocystic adnexal carcinomamucinous carcinomamyoepitheliomamyoepithelial carcinomapapillary digital adenocarcinoma / aggressive papillary digital adenomapapillary eccrine adenomasweat gland carcinomasyringocystadenoma papilliferumsyringoma / syringomatous carcinoma
• hair follicles: cutaneous lymphadenomafolliculofibromainverted follicular keratosiskeratinous cystkeratoacanthomapilar tumorpilomatrixomatrichilemmomatrichoepitheliomatrichofolliculomawarty dyskeratoma
• sebaceous glands: senile sebaceous hyperplasianevus sebaceus of Jadassohnsebaceous adenomasebaceous carcinoma

Premalignant / in situ: carcinoma in situ-generalactinic keratosisbowenoid papulosisBowen diseasePaget disease

Carcinoma (non adnexal): adenoid (acantholytic) squamous celladenosquamousbasal celllymphoepithelioma-likeMerkel cellMerkel-stagingmetastaticmucoepidermoidsmall cellspindle squamous cellsquamous cellverrucous carcinomastaging

Lymphoma and related disorders: generalacute lymphoblasticanaplastic large cellangiocentricblastic plasmacytoiddiffuse large B cellfollicularHodgkinHTLV-1intravascularJessner lymphocytic infiltration of skinleukemialymphoid hyperplasialymphomatoid papulosisMALTmantle cellmast cell disordersmycosis fungoidesNK/T cellperipheral T cellplasmacytomaprimary cutaneous (general)Woringer-Kolopp disease

Vascular tumors: acquired angiomaangiokeratomaangiosarcomabacillary angiomatosisbenign lymphangioendotheliomaglomushemangiomahemangioendotheliomainfantile (benign) hemangioendotheliomaintravascular papillary endothelial hyperplasiaKaposi sarcomaKimura diseaselymphangiomapyogenic granulomareactive angioendotheliomatosisvascular leiomyomaverruga peruana

Other tumors of skin: angiofibromaatypical fibrous histiocytomaatypical fibroxanthomabenign cystic teratomabenign fibrous histiocytoma (superficial)collagenous fibromaconnective tissue nevusdeep benign fibrous histiocytomadermatofibrosarcoma protuberansdermatomyofibromaendometriosisepithelial sheath neuromagranular cell tumorhamartoma of scalphistiocytomainclusion body fibromatosisinflammatory pseudotumorkeloidLangerhans cell histiocytosisleiomyomaleiomyosarcomamalignant fibrous histiocytomamalignant peripheral nerve sheath tumor (MPNST)meningiomameningioma-like tumor of skinmulticentric reticulohistiocytosisneurofibromaneurothekeomapalisaded encapsulated neuromaperineuriomapleomorphic fibromaRosai-Dorfman diseaseschwannomasclerosing fibromastriated muscle hamartomasuperficial angiomyxomasupernumerary digitxanthomaxanthogranuloma


Index (table of contents in alphabetical order)
A-E: acquired angiomaacquired digital fibrokeratomaacrosyringeal adenomatosisactinic keratosisacute lymphoblastic lymphomaadenoid cystic carcinoma (primary cutaneous)adenoid (acantholytic) squamous cell carcinomaadenosquamous carcinomaadnexal tumors-generalanaplastic large cell lymphomaangiocentric lymphomaangiofibromaangiokeratomaangiosarcomaapocrine cystadenoma / hidrocytomaapocrine glands-generalapocrine mixed tumorapocrine tubular adenomaatypical fibrous histiocytomaatypical fibroxanthomabacillary angiomatosisbasal cell carcinomabenign cystic teratomabenign fibrous histiocytoma (superficial)benign lymphangioendotheliomablastic plasmacytoid lymphomaBowen diseasebowenoid papulosisbronchogenic cystcarcinoma in situ-generalcarcinoma-stagingchondroid syringomaclear cell acanthomaclear cell carcinoma with comedonecrosisclear cell papulosiscollagenous fibromacongenital eccrine angiomatous hamartomaconnective tissue nevuscutaneous horncutaneous lymphadenomacystadenomadeep benign fibrous histiocytomadermatofibrosarcoma protuberansdermatomyofibromadermoid cystdiffuse large B cell lymphomaeccrine cylindromaeccrine poromaeccrine spiradenomaeccrine syringofibroadenomaendometriosisepithelial sheath neuroma

F-M: fibroepithelial polypfollicular lymphomafolliculofibromaglomusgranular cell tumorhair follicle nevushamartoma of scalphemangioendotheliomahemangiomahidradenoma / eccrine acrospiromahidradenoma papilliferumhistiocytomaHodgkin lymphomaHTLV-1 lymphomainclusion body fibromatosisinfantile (benign) hemangioendotheliomainflammatory pseudotumorintraepidermal epitheliomaintravascular lymphomaintravascular papillary endothelial hyperplasiainverted follicular keratosisJessner lymphocytic infiltration of skinKaposi sarcomakeloidkeratinous cystkeratoacanthomaKimura diseaseLangerhans cell histiocytosislarge cell acanthomaleiomyomaleiomyosarcomaleukemialymphangiomalymphoepithelioma-like carcinomalymphoid hyperplasialymphoma-generallymphomatoid papulosismalignant fibrous histiocytomamalignant peripheral nerve sheath tumor (MPNST)MALT lymphomamantle cell lymphomamast cell disordersmelanoacanthomameningiomameningioma-like tumor of skinMerkel cell carcinomaMerkel cell carcinoma-stagingmetastatic carcinomamicrocystic adnexal carcinomamucinous carcinomamucoepidermoid carcinomamulticentric reticulohistiocytosismycosis fungoidesmyoepitheliomamyoepithelial carcinoma

N-Z: neurofibromaneurothekeomanevus sebaceus of JadassohnNK/T cell lymphomaPaget diseasepalisaded encapsulated neuromapapillary digital adenocarcinoma / aggressive papillary digital adenomapapillary eccrine adenomaperineuriomaperipheral T cell lymphomapigmented follicular cystpilar tumorpilomatrixomapleomorphic fibromaplasmacytomaprimary cutaneous lymphoma (general)pseudoepitheliomatous hyperplasiapyogenic granulomareactive angioendotheliomatosisRosai-Dorfman diseaseschwannomasclerosing fibromasebaceous adenomasebaceous carcinomaseborrheic keratosissenile sebaceous hyperplasiasmall cell carcinomaspindle squamous cell carcinomasquamous cell carcinomasteatocystomastriated muscle hamartomasuperficial angiomyxomasupernumerary digitsweat gland carcinomasyringocystadenoma papilliferumsyringoma / syringomatous carcinomatrichilemmomatrichoepitheliomatrichofolliculomavascular leiomyomavellous hair cystverruca vulgarisverrucous carcinomaverrucous hyperplasiaverruga peruanawarty dyskeratomaWoringer-Kolopp diseasexanthomaxanthogranuloma


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Primary references

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AJCC Cancer Staging Manual (7th ed)



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