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Case of the Week #319
A 34 year old man with a history of multiple endocrine neoplasia type IIA presented with an adrenal gland mass.
What is your diagnosis?
Composite pheochromocytoma with ganglioneuroma
Immunostains were obtained:
Chromogranin is positive in pheochromocytes, weak in ganglion cells and negative in Schwann cells. Neurofilament is positive in the ganglion and Schwann cells, and is negative in the pheochromocytes. S100 is positive in Schwann and sustentacular cells surrounding the pheochromocytes, and is negative in the ganglion cells.